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bd40bc7c7a R. Between these two kinds of actions, the mitochondrial inhibition requires far less amounts of drugs and is greatly enhanced when the wasting pathway of heme is attenuated. (B) DHA does not affect the respiration ability of either WT or HEM2-KD strains on fermentable media. Mo, D. Thus, the role of heme may be associated with degradation instead of activation of ARTs aiding in the killing of parasite . Vattanaviboon, N.
Firestone, "Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene Expression", Journal of Biological Chemistry, vol. If this holds true, we would expect that an addition of ARTs would reduce the ETC/respiration activity of yeast cells. Moreover, modulating intracellular iron concentrations altered the effect of ARTs . Z. C. 4, pp. Taramelli, N.